Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation.
نویسندگان
چکیده
منابع مشابه
Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation.
Allopurinol ribonucleoside [4-hydroxy-1-P-D-ribofuranosylpyrazolo(3,4,-d)pyrimidine] was shown to be more effective than allopurinol in inhibiting the growth of Leishmania promastigotes in vitro. Both allopurinol and its ribonucleoside were equally effective in preventing the transformation of the intracellular form (amastigote) of Leishmania donovani to the extracellular form (promastigote). P...
متن کاملAntileishmanial effect of allopurinol.
Allopurinol (4-hydroxypyrazolo[3,4-d]pyrimidine) has been shown to inhibit the growth of Leishmania braziliensis in vitro at concentrations which are attainable in human tissues and body fluids. This compound is believed to act by interdicting the de novo synthesis of pyrimidines, probably through the formation of allopurinol ribotide. Its lack of toxicity makes it a potential candidate for ani...
متن کاملEnzymatic and metabolic studies with allopurinol.
Since the effectiveness of allopurinol as a xanthine oxidase inhibitor in vivo is the subject of this symposium, it seems appropriate to consider the nature of this inhibition in vitro and to examine the characteristics of distribution, clearance, and metabolic conversion of the drug which may add to or detract from its activity. The most readily available source of xanthine oxidase, and the mo...
متن کاملEffects of allopurinol on iron metabolism in man.
We have treated only eight patients with allopurinol, selected because their hyperuricaemia and gout were uncontrollable by standard measures, and because they were prepared for detailed and prolonged study. In view of the theoretical possibility that inhibition of xanthine oxidase might also have an effect in iron metabolism (Green and Mazur, 1957; Mazur, Green, Saha, and Carleton, 1958; Mazur...
متن کاملConnexin43 phosphorylation: structural changes and biological effects.
Vertebrate gap junctions, composed of proteins from the connexin gene family, play critical roles in embryonic development, co-ordinated contraction of excitable cells, tissue homoeostasis, normal cell growth and differentiation. Phosphorylation of connexin43, the most abundant and ubiquitously expressed connexin, has been implicated in the regulation of gap junctional communication at several ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1979
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)86518-3